Dr Nupam Mahajan is a Professor of Surgery, Director of Urological Research and an Endowed Professor of Cancer Research at Siteman Cancer Center, Washington University in St. Louis.
He has over a decade of experience in developing new classes of anti-cancer drugs and taking the compounds into the clinical trials. He has developed the compound (R)-9b which has completed extensive pre-IND studies and filed for IND. The Phase I clinical trial for prostate and breast cancer patients will start in early 2025.
The data indicates that (R)-9b is the next generation of AR-antagonist with immune modulatory properties. This clinical trial PHAROS is directed towards a Phase 1, First in Human Trial to Assess Safety and Tolerability of the Novel ACK1 Inhibitor (R)-9b in Patients with Prostate Cancer (acronym: PHAROS) and will examine its ability to suppress tumor growth and stimulate anti-tumor immune responses.
Mr Nemeth is a founder director of the company. He has over 2 decades of experience with working on various Wall Street Companies, including MS Farrell. His experience has been critical for development of TechnoGenesys as a therapeutic company with multiple IPs.
Dr Gerald L. Andriole is the global Chief Medical Officer at Prostatype Genomics. He previously was Professor and Director of Urology in the National Capital Region at the Brady Urologic Institute at Johns Hopkins University. He also formerly served as the Robert K. Royce Distinguished Professor and Chief of Urologic Surgery at Barnes-Jewish Hospital, the Siteman Cancer Center, and Washington University School of Medicine in St. Louis, Missouri.
Dr. Andriole has over 40 years of consistent contributions in the areas of prostate cancer screening and prevention research as well as BPH. He has led the USA’s largest randomized prostate cancer screening trial (NIH PLCO trial) and the international REDUCE prostate cancer chemoprevention trial.
He has contributed over 450 peer-reviewed publications. He chaired the Prostate Committee of NCI’s PLCO Cancer Screening Trial, the Steering Committee of the international REDUCE Chemoprevention Trial and the Prostate Committee of the SUO Clinical Trials Consortium. He is a member of the American Urological Association, the Academy of Master Surgical Educators of the American College of Surgeons, the American Surgical Association, the American Association of Genitourinary Surgeons, and the Clinical Society of Genitourinary Surgeons, among other societies.
Dr Kiran is an Assistant Professor in Department of Surgery, and at Siteman Cancer Center, Washington University in St. Louis.
She has extensive experience in testing inhibitors in various animal models and deciphering the mechanism of action. She has been involved in development of the compound (R)-9b, which is going to be in clinical trial.
Dr McLaughlin’s is expert in anticancer drug discovery and development focused on protein-protein interaction inhibitor design, molecularly targeted radiotherapy, and molecularly targeted immunotherapy for the treatment/cure of targeted cancers.