(R)-9b, a novel small molecule, AR-antagonist
(R)-9b is a small molecule inhibitor that suppresses activity of AR-interacting tyrosine kinase, ACK1 (also known as TNK2). ACK1/AR complex regulates AR and AR-V7 expression. By virtue of ACK1 inhibition, (R)-9b suppresses not only AR (and AR-V7) expression, but also overcomes tumor growth of Castration Resistant Prostate Cancer (CRPC). Significantly, (R)-9b sensitizes Enzalutamide and Abiraterone-resistant prostate cancer, opening a new therapeutic modality for these patients, a critical unmet need.